Go through these in order and stop at the first one that applies. If you are reading this for someone else, answer for them.
Seek emergency help if swelling of the face, lips, tongue, or throat develops after using a skin product, particularly with trouble breathing, wheezing, faintness, or widespread hives.
This could be a serious allergic reaction.
Arrange same-day care if the area becomes rapidly more red, hot, swollen, or painful, especially if redness is spreading or you develop a fever.
These changes may suggest infection or another condition rather than uncomplicated comedones.
Book a routine appointment if they persist despite consistent self-care, are getting worse, leave dark marks or scars, or affect how you feel about your appearance.
You should also seek advice if you are unsure whether the bumps are comedones.
The article also says
Comedones alone are not usually urgent.
Every sign above is quoted from the sofidex article on Comedones. If you are not sure, err upward — it is always reasonable to be checked.