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Warning-sign checks

Multiple endocrine neoplasia (MEN) II: when to get help

Go through these in order and stop at the first one that applies. If you are reading this for someone else, answer for them.

  1. 1

    Is any of this happening now?

    Call 911

    Call emergency services for chest pain, severe shortness of breath, fainting, new weakness on one side, confusion, or a severe headache with a racing heartbeat and sweating.

    If you have adrenal insufficiency, follow your emergency plan during vomiting, serious illness, injury, or an adrenal crisis.

    Severe weakness, repeated vomiting, fainting, confusion, or inability to keep replacement medicine down requires emergency care.

    Other emergency signs, for anyone
    • Someone who is struggling to breathe, gasping, choking, or cannot get words out
    • Someone who has chest pain, tightness or pressure lasting more than a few minutes
    • Someone who has sudden weakness or drooping on one side of the face or body, slurred speech, or sudden confusion
    • Someone who is unconscious, or cannot be woken
    • Someone who is bleeding heavily and it will not stop with firm pressure
    • Someone who has had a seizure that will not stop, or does not wake up afterwards
    • Someone who has lips or skin that look pale, blue, grey or blotchy
    • Someone who you believe has taken an overdose or swallowed something poisonous
  2. 2

    Is any of this happening?

    Be seen today

    Seek urgent medical care for repeated episodes of severe headache, pounding heartbeat, sweating, or very high blood pressure.

    These can be signs of a pheochromocytoma releasing excess hormones.

  3. 3

    Does any of this apply?

    Book an appointment

    Arrange routine medical follow-up if you have a RET variant, even when you feel well.

    Contact your MEN2 team if you develop a new neck lump, ongoing hoarseness, trouble swallowing, repeated headaches with sweating or palpitations, kidney stone symptoms, or persistent digestive changes.

Every sign above is quoted from the sofidex article on Multiple endocrine neoplasia (MEN) II. If you are not sure, err upward — it is always reasonable to be checked.