Go through these in order and stop at the first one that applies. If you are reading this for someone else, answer for them.
1
Is any of this happening now?
Call 911
Follow any condition-specific emergency plan you have been given.
People with severe immune deficiencies may need assessment earlier than someone with a healthy immune system.
Call emergency services for severe breathing difficulty, blue or grey lips, confusion, collapse, a seizure, extreme difficulty waking, or signs of a rapidly worsening infection.
A stiff neck with fever, a non-fading rash, or severe dehydration also needs emergency assessment.
Other emergency signs, for anyone
Someone who is struggling to breathe, gasping, choking, or cannot get words out
Someone who has chest pain, tightness or pressure lasting more than a few minutes
Someone who has sudden weakness or drooping on one side of the face or body, slurred speech, or sudden confusion
Someone who is unconscious, or cannot be woken
Someone who is bleeding heavily and it will not stop with firm pressure
Someone who has had a seizure that will not stop, or does not wake up afterwards
Someone who has lips or skin that look pale, blue, grey or blotchy
Someone who you believe has taken an overdose or swallowed something poisonous
2
Is any of this happening?
Be seen today
Contact your usual medical team promptly if:
A fever or infection is worsening rather than improving
You cannot keep down fluids or medicines
A wound becomes increasingly red, painful, or swollen
You develop a new persistent cough, breathlessness, or chest pain
You have been exposed to a significant infection covered by your care plan
3
Does any of this apply?
Book an appointment
Routine follow-up is important even when you feel well.
Arrange a non-urgent review if infections are becoming more frequent, your usual treatment is less effective, or new symptoms such as weight loss, persistent diarrhoea, swollen joints, or ongoing cough appear.
And for anyone, someone who:
has noticed a lump, a mole that has changed, or unexplained weight loss
Every sign above is quoted from the sofidex article on Primary immunodeficiency. If you are not sure, err upward — it is always reasonable to be checked.