Go through these in order and stop at the first one that applies. If you are reading this for someone else, answer for them.
1
Is any of this happening now?
Call 911
Seek urgent or emergency care for:
Severe or sudden breathlessness
Chest pain, fainting, or new confusion
Very little or no urine
Vomiting blood or passing black, tar-like stool
Sudden painful swelling in one leg
Severe weakness with dizziness or very low blood pressure
These symptoms can have several causes.
Other emergency signs, for anyone
Someone who is struggling to breathe, gasping, choking, or cannot get words out
Someone who has chest pain, tightness or pressure lasting more than a few minutes
Someone who has sudden weakness or drooping on one side of the face or body, slurred speech, or sudden confusion
Someone who is unconscious, or cannot be woken
Someone who is bleeding heavily and it will not stop with firm pressure
Someone who has had a seizure that will not stop, or does not wake up afterwards
Someone who has lips or skin that look pale, blue, grey or blotchy
Someone who you believe has taken an overdose or swallowed something poisonous
2
Is any of this happening?
Be seen today
If you have already been diagnosed, contact your care team promptly about increasing swelling, a clear drop in urine output, repeated vomiting or diarrhea, signs of infection, or a flare of your underlying inflammatory condition.
They need urgent assessment whether or not they are related to amyloidosis.
3
Does any of this apply?
Book an appointment
Arrange a routine medical review if you develop persistent foamy urine, ankle swelling, ongoing diarrhea, unexplained weight loss, increasing fatigue, or reduced appetite.
These symptoms are not specific to amyloidosis, but they may need blood and urine testing.
These may require earlier assessment rather than waiting for a routine appointment.
Every sign above is quoted from the sofidex article on Secondary systemic amyloidosis. If you are not sure, err upward — it is always reasonable to be checked.